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The role of copper in this regard is argued to be protective, with copper being released into the synaptic cleft at concentrations of up to 100 M upon depolarization, inhibiting the activity of postsynaptic NMDA, AMPA, and GABA receptors upon binding, thus preventing overstimulation in a negative feedback system (DAmbrosi and Rossi, 2015)

Arch Med Sci 17:523534

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The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage