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Semaglutide is the most extensively studied GLP-1RA, with multiple trials, including SUSTAIN-6, PIONEER-6, FLOW, and SOUL [20,21,22, 31], collectively establishing a robust evidence base for cardiorenal risk reduction in T2D, with SELECT extending these benefits to adults with overweight/obesity and established ASCVD without diabetes [32]

Across two treatment sessions and six months of follow-up, patients lost an average of 24.3 pounds about 9.2% of starting body weight and their measured facial metrics held steady or improved

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