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Safety considerations include contraindications in personal or family history of medullary thyroid carcinoma, contraindications in pregnancy, and monitoring for gastrointestinal side effects
Safety monitoring should include periodic IGF-1 levels and fasting glucose checks, as growth hormone stimulation can affect glucose metabolism
Clinical trials establishing tirzepatide's safety and efficacy were conducted using the standard once-weekly schedule at designated dose intervals
It reflects a genuinely novel mechanism that explains why the clinical outcomes have been so striking, not just for diabetes and weight loss, but potentially for conditions like PCOS where metabolic dysfunction drives the disease
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