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Given the dose-dependent effects and improved management of tolerability within the GLP-1RA class, the aim of this trial was to characterize the dose-dependent effects of subcutaneous semaglutide at doses up to 16 mg weekly (2 mg, 8 mg, 16 mg, and pooled placebo) in individuals with type 2 diabetes and overweight or obesity (BMI 27 kg/m 2 )

In addition to glucose control, emerging evidence suggests semaglutide may exert anti-inflammatory effects and improve vascular health by reducing inflammatory cytokines