glp-1 news october 21 2025 New Pill Foundayo (Orforglipron) Gets FDA Approval for Obesity What to Know About the

When IV therapy for teens is on the table, most qualified candidates are offered basic saline hydration or carefully dosed formulas rather than the full adult menu

Nat Cell Biol 18:1269

Hannan, M.A., et al

Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists