In the present study, we: 1) assessed the functional role of endogenous VTA GLP-1 signaling in cocaine seeking using projection-specific chemogenetic approaches, 2) determined cell type-specific expression patterns of GLP-1Rs in the VTA using fluorescent in situ hybridization (FISH) and single nuclei RNA-sequencing (snRNA-seq) methods, and 3) used in vivo fiber photometry in freely moving transgenic rats to further our understanding of the cell type-specific mechanisms in the midbrain underlying the suppressive effects of a GLP-1R agonist on cocaine seeking
Starting with one from Endocrine Reviews from May 2024 by Hoong-Wei Gan, Manuela Cerbone, and Mehul Tulsidas Dattani, Appetite- and Weight-Regulating Neuroendocrine Circuitry in Hypothalamic Obesity , says Abel, provided a comprehensive overview of the complex interacting pathways by which the hypothalamus receives numerous peripheral hormonal signals from the gut and adipose tissue, such as leptin, ghrelin, glucagon-like peptide 1 (GLP1), and others and integrate these to regulate feeding behavior, energy expenditure, and body weight
Serious side effects are rare but can include pancreatitis (pain in the upper abdomen), severe allergic reactions, and thyroid concerns in predisposed individuals
Q11: What is the best time of day for tesamorelin
