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Similarly, mice exposed to CUMS for 6 weeks showed an increased interferon-gamma (IFN-) and decreased anti-inflammatory IL-10 levels, demonstrating anti-inflammatory suppression with further pro-inflammatory activation (Jia et al., 2024)

While early medications showed promise, they were limited by todays standard, and they came with notable challenges

A: Primarily formulated for the face, this cream can also be applied to the neck and other localized areas with pigmentation or discoloration for targeted brightening

Causes: Physiologic common in skin of color patients Frictional (especially 4 th and 5 th toenails) Behavioral: Habit-tic deformities B