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They are more often observed on fingernails than toenails

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Significant evidence from large, randomised trials has shown that SGLT2Is have a positive impact on heart failure with reduced ejection fraction (HFrEF) as well as on HFpEF

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Geriatr Gerontol Int 10(Suppl 1):S99S106 Al-Majed AA, Sayed-Ahmed MM, Al-Omar FA, Al-Yahya AA, Aleisa AM, Al-Shabanah OA (2006) Carnitine esters prevent oxidative stress damage and energy depletion following transient forebrain ischaemia in the rat hippocampus

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This process weakens the cellular antioxidant defense, accelerating chondrocyte death and the progression of OA pathology

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