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2.6.3.1.1 Small molecule TKIs A retrospective study of 126 patients with HER2+ BCBM, including 47 treated with lapatinib, demonstrated that SRS combined with lapatinib improved intracranial local failure (2-year: 6.5% vs 18.0%, P 70% FSRT) reported a 1year ICPFS of 74.9% and no symptomatic RN, with mOS not yet reached ( 2.6.3.1.2 Monoclonal antibodies and ADCs The study by Miller et al

DSIP typically comes from the pancreas and gut secretory cells

It is specifically characterized by inflammation, demyelination, and neuronal loss and manifests with a range of neurological symptoms including numbness, tingling, vision impairment, cognitive impairment, and bladder and bowel dysfunction (Tafti et al., 2024)

studies show that even high oral doses may not significantly raise systemic levels in a robust way