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Consistent with the previous global PIONEER trials, few SAEs were reported across treatment arms and most were reported in the oral semaglutide 3 mg and sitagliptin 100 mg treatment arms

This was attributed to an increase in the activity of superoxide dismutase, glutathione peroxidase, and glutathione S-transferase, while also reducing malondialdehyde and ROS content (Honardoust et al., 2021)

However, it's important to recognize that there are many alternatives available that can also help individuals achieve their health goals

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