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High-dose supplementationparticularly intramuscular injections that can deliver 1,000 micrograms or morecreates substantially elevated serum B12 levels compared to dietary intake, which may more readily trigger these bacterial changes, though comparative studies between different forms are limited

The advantages of B12 therapy are comprehensive, affecting nearly every major system in the body

Muscle contractile function was markedly restored, accompanied by significantly elevated proliferation activity and number of muscle stem cells, as well as upregulated expression of myogenic differentiationrelated genes

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