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Although bariatric surgery can lead to weight loss of at least 25% and long-term weight maintenance, it is not scalable at the population level, and many people are still afraid to have surgery because of the possibility of complications, [135, 136]

Their co-targeting, particularly through intelligent NDDS, is not merely additive but potentially synergistic, offering a promising avenue to dismantle multiple pillars of tumor survival simultaneouslymetabolic adaptability, antioxidant defense, and immune evasion

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