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(3) inability to follow up regularly (4) known intolerance or hypersensitivity to GLP-1RA therapy, including significant gastrointestinal adverse reactions (such as persistent nausea, vomiting, or diarrhea) or severe hypoglycemic episodes that would preclude continued use of the drug

However, poor SubQ technique (injecting too quickly or using a dull needle) can cause equivalent discomfort, so proper execution matters more than route selection alone

doi: 10.1046/j.1471-4159.1998.71010366.x 51 GalassiF

In clinical contexts, it is not presented as a rapid or universal solution, but as a compound that may be considered within a broader treatment strategy