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The synthetic TB-500 represents the active segment of T4, focusing on a specific portion believed to drive its biological activity

Moreover, skeletal muscle injury models have suggested a beneficial effect not only for disturbances that occur as a result of direct trauma but also for systemic insults including hyperkalemia and hypermagnesia

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Accordingly, these principles have been therapeutically exploited in nanomedicine platforms designed to induce GSH-dependent ROS amplification (Fig