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Meta-analyses report substantial heterogeneity in outcome definitions and study design, limiting comparability and mechanistic interpretation 68,69

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148 Thus, if the strength of the particular beneficial effect is the most important proof of the concept with the prostaglandins and other standard cytoprotectants, we have to admit that Roberts stomach cytoprotection/adaptive cytoprotection/organoprotection tolerates no recovery of the preexisting stomach lesions, providing only prophylactic effect