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Keep notes on DSIP dose and timing, sleep quality ratings, number of awakenings, morning energy levels, and any other factors you want to monitor

However, under insulin-resistant conditions, the regulation of acetyl-CoA carboxylase becomes disrupted, leading to sustained elevations in malonyl-CoA and consequent inhibition of CPT1 activity [118], with consequent cytosolic accumulation of these substrates [119]