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Figure 19: LS Mean Change from Baseline in Monthly Average Nasal Congestion (NC) Score Up to Week 52 in Subjects 6 Years of Age and Older with AFRS (AIMS - ITT Population) Figure 20: LS Mean Change from Baseline in Nasal Polyp Score (NPS) Up to Week 52 in Subjects 6 Years of Age and Older with AFRS (AIMS - ITT Population) Systemic Corticosteroid Use and/or Sino-Nasal Surgery DUPIXENT reduced the proportion of subjects receiving systemic corticosteroids and/or undergoing sino-nasal surgery by 92% compared to placebo (HR of: 0.079

This mechanism may contribute to both cardiovascular effects through vasomotor tone regulation and neuroprotective effects in central nervous system injury models