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They are formed in the body from normal metabolism (such as converting food to energy) but are increased by exposure to environmental toxins, such as cigarette smoke and air pollution

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To test for shifts in cluster composition between two conditions, we used the scProportionTest, which generates a P value per cluster by permuting L-serine-treated groups and quantifies uncertainty in the predicted proportion difference

(2017) also found that the expression of the transcription factor OCT 4 may be related to the poor efficacy of tamoxifen, and its expression level can be used to predict the sensitivity of breast cancer cells to tamoxifen