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How clinicians might think about this (risk vs benefit) GLP-1 receptor agonists have benefits that are not small: strong glucose lowering in many patients weight loss benefits in certain populations, cardiovascular risk reduction sometimes improved adherence compared to multiple daily pills because of weekly dosing options So for many patients, the benefit side of the equation is heavy

Meanwhile, liraglutide's share decreased from 42% to 12% among users with diabetes and from 58% to 21% among those without diabetes, although its estimated absolute number of users without diabetes increased

At any rate, in two clinical trials, magnesium supplementation did indeed improve adult ADHD symptoms

But issues can arise e.g., impurities, immunogenicity to cause concern