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Diphthamide biosynthesis genes are essential to normal development, and deletion of these genes in mice leads to developmental defects including embryonic lethality, while mutations found in humans are associated with developmental delays, intellectual disability, craniofacial and genital abnormalities (Nakajima et al, 2018)

Barring such a hypothesis, I wonder about the meaning of such phenotype in terms of longevity and health

Clinical trials have demonstrated that GLP-1 agonists can reduce the risk of major adverse cardiovascular events such as heart attack, stroke, and cardiovascular death [5, 7]

The current litigation reflects that shift: plaintiffs allege that effects on the gastrointestinal system can, in some cases, progress into diagnosed motility disorders and related injuries requiring emergency evaluation, hospitalization, specialist care, and repeated diagnostic testing