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Clinicians typically assess treatment continuation at regular intervals, evaluating several factors: achievement of therapeutic goals (A1C reduction of 0.5-1% or weight loss of 5-15% or more), absence of intolerable adverse effects, patient adherence and satisfaction, and cost-effectiveness
But quick changes are disorienting too
Gastrointestinal symptoms (nausea, diarrhea, constipation, abdominal pain) are most common, typically occurring during dose escalation and often improving with continued use
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