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A meta-analysis of GLP-1RA CVOT showed that treatment with GLP-1RA reduced the risk of developing a composite kidney outcome including new-onset MA by 21% compared to placebo (HR 0.79, 95% CI 0.73-0.87), with only ELIXA and EXSCEL not achieving significant benefit [11]

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Additionally, in vitro whole-cell recordings from acute brain slices revealed that NAC displayed a dual, concentration-dependent influence on evoked glutamatergic synaptic currents in the NAc core: lower concentrations diminished amplitude through mGluR2/3 activation, whereas higher concentrations augmented amplitude via mGluR5 activation [12]