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10.1161/CIRCEP.122.011160 175 ZhangL.LuanY.DingX.YangC.XingL.ZhangH.et al (2024)

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[3] Peroxisomes are involved in the catabolism of very long chain fatty acids, branched chain fatty acids, bile acid intermediates (in the liver), D-amino acids, and polyamines

If side effects worsen after switching to split dosing, it may indicate a measurement error resulting in inadvertently higher individual doses, or it may suggest that your side effects are not primarily driven by peak concentration