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Additionally, catalpol inhibits the activation of the nucleotide-binding oligomerization domain containing 2 (NOD2)/NF-B/mitogen-activated protein kinase (MAPK) signaling pathway, playing an anti-inflammatory and protective role in mouse chondrocytes

At the same time and less obviously many other areas are affected, in which cell division plays a major role, including in the brain and spinal cord

doi: 10.3389/fmolb.2024.1403727

GH altered the cytokine environment, triggered anti-inflammatory macrophage (M2) polarization, maintained activity of the suppressor T-cell population, and limited Th17 cell plasticity (49)