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per os (including oral gavage, tube feeding, intramuscular or intravenous)

The condition must be confirmed by genetic testing demonstrating variants in POMC, PCSK1, or LEPR genes that are interpreted as pathogenic, likely pathogenic, or of a variant of uncertain significance (VUS)

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The next paragraphs will discuss genetic predisposition and susceptibility as an underlying risk factor for ME/CFS - the superimposition of external stressors and exposures (59) results in a state of aberrant homeostasis, where a temporary homeostatic state of functioning occurs, but functions at a less optimum level (64)