Activation of these proteins contributes to actin cytoskeleton remodeling and changes in cell migration behavior
Jos Morales, MD, a vascular neurologist and neurointerventional surgeon at Providence Saint Johns Health Center in Santa Monica, CA, also not involved in this review, told MNT that microglias effect on the neurovascular unit has been associated with dementia. He suggested that: [GLP-1 drugs] could potentially modulate inflammation to reduce the propensity for developing dementias such as Alzheimers disease, particularly in the setting of metabolic syndrome. Morales also explained that in people who have glycemia or type 2 diabetes, the inflammation of the blood-brain barrier can lead to progressive damage to the brain over longer periods. He noted that trials that combine neuroimaging techniques that measure the blood-brain barrier and GLP-1 treatment are needed and could prove that these drugs have neuroprotective benefits.
Work in human biopsy models has shown that IL-12p35 was not expressed within psoriatic skin lesions, whereas p40 in IL-12 and IL-23, along with IL-23p19, were significantly expressed
[DOI] [PubMed] [Google Scholar] 11.Hardeland R., Reiter R.J., Poeggeler B., Tan D.X
