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Similar content being viewed by others Introduction Electrophilic compounds that form a covalent bond with their targets were historically avoided from drug discovery pipelines due to concerns about potential idiosyncratic toxicity and other pharmacological challenges related to insufficient selectivity 1,2
Fourteen Participants A study reported shorter sleep-onset latency, less wakefulness after sleep onset and longer total sleep time following repeated intravenous exposure
It has been suggested that thiazides may work better if used in combination with potassium citrate therapy and a low-salt diet (Sakhaee, Maalouf 2012)
Burgmaier M, Liberman A, Mollmann J, Kahles F, Reith S, Lebherz C, et al
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