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However, in a much larger randomized controlled trial of simvastatin and an antioxidant combination of 600 mg of all - rac --tocopherol (297 mg of RRR --tocopherol), 250 mg of vitamin C, and 20 mg of -carotene daily) in more than 20,000 men and women with CHD or diabetes mellitus, the antioxidant combination did not adversely affect the cardioprotective effects of simvastatin therapy over a five-year period (131)

Only in the 20th century were the pathways of production of uric acid in the body truly understood and clarified, and it was proved that uric acid crystals have the ability to produce joint inflammation

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Some studies included children with and without intellectual disability with no differentiated results (Hardan et al., 2012), which could confound the net effects of antioxidant-based therapies in this population and hinder the differentiation of clinical responses in ASD patients with intellectual disabilities