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At differentiation stage of brain development, EZH2 is required for switching Intermediate Progenitors cells fate from neurogenic to astrogenic by H3K27 trimethylation of Neurog1 promoter (Figure 2).One of the well-known pieces of evidence showcasing the role of PRC2 complex in neurodevelopment comes from Weaver syndrome (WVS) studies

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Importantly, all GLP-1 receptor agonists carry a boxed warning about the risk of thyroid C-cell tumors and are contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2