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SIRT1 may reduce NET formation by deacetylating FOXO1 and increasing the expression of the pro-apoptotic protein Bim, which destabilizes mitochondrial membranes by interacting with anti-apoptotic members of the Bcl-2 family and shortens neutrophil survival, limiting their accumulation in liver tissue

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388 Similarly, aluminium and manganese reduce astrocytic glutamate uptake, thus leading to excitotoxicity and secondary neuronal death