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Arthritis Res

The following criteria were considered: Full economic evaluations: cost-utility analysis, cost-effectiveness analysis, cost-benefit analysis Economic evaluations reporting incremental cost-effectiveness ratios (i.e., cost per quality-adjusted life year/life years gained or cost per event avoided) Studies in patients with confirmed vitamin B12 deficiency Studies in English Abstracts were reviewed by a single reviewer and, for those studies meeting the eligibility criteria, full-text articles were obtained

Although your body is unable to generate B-12, the vitamin is readily available from dietary sources including dairy, meat and fish

Mechanistically, cleavage of an amide-linked PAB triggers a 1,6-elimination of carbon dioxide as well as the concomitant release of free drugs in the parental amine form