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Expression profiles are redirected towards signatures characteristic of young tissues (Pickart & Margolina, Int J Mol Sci 2018)

Design and development of microsomal prostaglandin E 2 synthase-1 inhibitors: challenges and future directions

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In addition, ROS mediate cysteine sulfenylation of another ER stress sensor, inositol requiring enzyme 1 (IRE1), which activates nuclear factor-E2-related factor-2 (Nrf2) to generate an antioxidative response (Hourihan et al., 2016)