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The DHFR 19-bp deletion allele thus interferes with folate metabolism and the transport of reduced folate across the placenta

The overall matched cohorts contained 47,199 patients per arm and were closely balanced for age at the index event (59.4 versus 59.9 years), female representation (62.8% versus 61.3%), baseline BMI (35.6 versus 35.3 kg/m 2 ), and baseline documented type 2 diabetes prevalence (25.8% versus 26.0%) (Table 2)

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Khajavi N, Finan B, Kluth O et al (2018) An incretin-based tri-agonist promotes superior insulin secretion from murine pancreatic islets via PLC activation