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Immune cells Lactate/lactylation induces the generation of immunosuppressive TME in diverse types of tumors 271,272,273,274,275 (Table 1)

Because reactive oxygen and nitrogen species also participate in physiological signaling and cellular adaptation, broad suppression of oxidative pathways may not always be beneficial

This study is encouraging, suggesting an increased SVR and fewer adverse events when standard combination therapy is used to treat children as compared with adults