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Gradual dose escalation can help minimize GI symptoms like nausea or abdominal pain

Tirzepatide (Mounjaro, Zepbound) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management (Mounjaro) and chronic weight management (Zepbound)

This means the approach is based on pharmacological principles, clinical observation, and real-world reports rather than gold-standard evidence

It allows the drug to bind to human serum albumin in the bloodstream, extending its half-life to approximately five days and enabling once-weekly dosing