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Metformin HCl Long-term carcinogenicity studies have been performed in rats (dosing duration of 104 weeks) and mice (dosing duration of 91 weeks) at doses up to and including 900 mg/kg/day and 1,500 mg/kg/day, respectively

Consequently, tissue-level outcomes may depend not only on receptor activation but also on the availability of metabolic substrates required to sustain bioenergetic and redox balance under conditions of reduced nutrient inflow