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doi:10.2337/dci24-0091

Generally, OPFRs [428] exhibited much lower toxicity than BFRs [421, 422] towards human erythrocytes

Tachyphylaxis is contingent upon a full 24-hour exposure, as evidenced by a study in which rats treated with liraglutide (with half-life of 11 15 hours) twice daily for 14 days had markedly diminished gastric emptying while those treated with exenatide (with half-life of 2 3 hours) twice daily over the same period still displayed a profound reduction in gastric emptying, although both compounds had similar effects on body weight reduction (158)

(2003) Sympathetic control of white adipose tissue in lean and obese humans