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Some serious side effects that have been reported with Invokana include: dehydration, which can cause hypotension (low blood pressure) lower limb amputations (surgery to remove a toe, foot, or part of your leg)* serious urinary tract infection (UTI) hypoglycemia (low blood sugar) increased risk of broken bones kidney damage* rare but serious infection of the genital area (Fourniers gangrene) diabetic ketoacidosis (high levels of ketones in your blood or urine) allergic reaction* If you develop serious side effects while taking Invokana, call your doctor right away

Psychiatry 2 , e134 (2012)

Its diversity and vulnerability make the involved pathway proteins potential therapeutic targets (Valdecantos et al., 2024)

The widespread promotion of the drug, including on TV ads, streetcar wraps, sports games and social media, reinforces the idea that weight loss should always be the end goal