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These symptoms can overlap with and potentially worsen the gastrointestinal effects already associated with GLP-1 therapy, making it difficult to distinguish which agent is responsible for adverse effects

Ten isolated rat islets were placed into each of eight channels that were operating at a flow rate of 50 L/min of KRB (continuously equilibrated with 21% O 2 and 5% CO 2 and balance of N 2 ) containing 0.1% BSA and 3 mM glucose for 90 min

The multinomial regression analysis indicated that patients with the lowest tertile exhibited elevated UA levels (odds ratio [OR]

Weight of evidence: Overall evidence is Low : primarily preclinical with heterogeneous designs and no consistent human biomarkers