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Common MCAS triggers include: Stress and emotional pressure Sudden temperature changes Exercise, including mild to moderate activity Being fatigued Certain food and beverages, including alcohol Prescription, over-the-counter, and illegal drugs Perfumes and chemical odors Naturally occurring odors in the environment Poisons and venoms Viral and bacterial infections Friction from clothing and shoes Mechanical irritation, like vibration Sun exposure Symptoms range from mild and somewhat tolerable to severe and life-threatening

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The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease

Apr 2014;101(4):941-4