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In summary, future clinical trials should prioritize enrolling individuals at risk, followed by those in the early stages of the disease, as this offers a higher likelihood of demonstrating neuroprotective and disease-modifying effects

In experimental models, OLETF rats have shown local RAS activation, which resulted in oxidative stress and kidney progressive damage, whereas treatment with dapagliflozin remarkably lowered the urinary ANG II and AGT levels (47)