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These free radicals can damage our cells and DNA, leading to various health issues, including aging and chronic diseases

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Recent research advancements indicate that the central nervous system symptoms associated with PEM, particularly fatigue and pain, can be conceptualized as interoceptive dysregulation. Interoception refers to the process by which the central nervous system perceives, interprets, and integrates internal physiological signals from the body (147)

This may contribute to fatigue, reduced endurance, cognitive variability or worsening during infection and other metabolic stress