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Third, individual variation is substantial: patients with severe insulin resistance or significant mitochondrial dysfunction may respond at lower doses than metabolically healthy athletes

Any interpretation beyond laboratory research is speculative

The selectivity of the peptide is further discussed by the researchers, who suggest that senescent cells may depend more strongly on FOXO4-mediated control of p53 localization and activity, so disrupting that node might preferentially remove cells that are already operating close to an apoptotic threshold

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