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In addition, two large-scale, double-blind, placebo-controlled phase 3 clinical studies called Evoke and Evoke + are underway to investigate the disease-mitigating potential of semaglutide in patients with AD with early symptoms and to explore its effects on AD biomarkers and neuroinflammation (Cummings et al., 2025)

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These include mild redness and swelling that resolves within hours, occasional bruising (typical of any subcutaneous injection), and mild burning or cramping reported by some users