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These nutrient-based secretagogues include: Dietary lipids, especially triacylglycerol which is the primary fat found in foods Dietary carbohydrates, particularly those yielding glucose Short chain fatty acids (SCFAs) produced from fiber fermentation by gut microbes The high density of L-cells in the large intestine makes it a prime target for SCFA-mediated GLP-1 secretion

The 2028 LOE event will be the largest single LOE in pharma history measured by pre-LOE sales

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The decrease between the 1970s and the 1980s coincided with the emergence of reninangiotensin system (RAS) blockers, but the conspicuous lack of further improvements after the 1980s highlights the need for additional kidney-protective medications [4]