Thiamine deficiency adversely affects the activity levels of these enzymes, with TK, through thiamine-dependent erythrocyte transketolase (ETK) activity, common biomarkers of thiamine status, since it is particularly sensitive to thiamine levels and AKD often exhibiting the earliest detectable changes (, )
These include: Headaches the most frequent side effect, occurring in approximately 1015% of users, caused by the vasodilatory effects of the medication Facial flushing a sensation of warmth and redness in the face and neck Indigestion or dyspepsia stomach discomfort or acid reflux Nasal congestion a blocked or stuffy nose Dizziness particularly when standing up quickly, due to temporary blood pressure changes Some men may experience visual disturbances , such as a blue tinge to vision, increased sensitivity to light, or blurred vision
Smaller peptides have fewer vulnerable residues and less complex three-dimensional structures that can unfold
Kaur G, Sankrityayan H, Dixit D, Jadhav P
