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Non-use of hormonal treatments in the 3 to 6 months prior to inclusion is often specified (and sometimes non-use of anti-inflammatory drugs in the days before inclusion), explaining why only 3% of the analysed publications adjust results for hormonal or symptomatic treatments (anti-inflammatory, painkillers, etc

Peer review Peer review information Nature Reviews Nephrology thanks Ling Zheng, Sarantos Kostidis and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

NAC is also an antioxidant itself as a source of sulfhydryl groups in cells and scavenger of free radicals as it interacts with reactive oxygen species such as OH and H 2 O 2 60

AharonySMLamOCorcosJ.Evaluation of lower urinary tract symptoms in multiple sclerosis patients: review of the literature and current guidelines