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Parallel to the findings from rat liver mitochondria, it has been recently reported that mitochondrial cholesterol enrichment, resulting in mGSH depletion, is a major mechanism of anthrax lethal toxin-induced macrophage cell death (Ha et al., 2012)

ReadyRx glutathione should be stored according to specific instructions provided with shipments, typically including refrigeration at 36-46F (2-8C) to maintain potency and stability, protection from light by keeping vials in original packaging until use, avoiding freezing which can damage the formulation, and checking expiration dates and discarding expired products appropriately

Ye Z, Zhuo Q, Hu Q, Xu X, Mengqi L, Zhang Z, et al

Such oxidative thiol modifications lead to a change in the structure of proteins and cause either their activation (e.g., in hRas-Cys-118 [70] and mitochondrial glutathione S-transferase [71]) or inactivation (e.g., in phospho-fructokinase [72] and nuclear factor kappa B (NFB) [73])