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2024 Meta-Analysis Indicates That GLP-1RAs Reduce Adverse CV Events A 2024 Meta-analysis of 13 multiple cardiovascular outcome trials has documented that GLP1-RA therapy significantly reduces the risk of major adverse cardiovascular events (MACEs), all-cause mortality, CV mortality, stroke, risk for coronary revascularization, and composite adverse kidney outcomes in both sexes, regardless of a patient's history of cardiovascular disease, BMI or eGFR (Rivera et al, 2024)

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However, if an injection site becomes infected (showing increasing redness, warmth, pain, pus formation, or fever), regional lymph nodes may respond by enlarging as part of the normal immune response

J Clin Endocrinol Metab 103: 21362146, 2018