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IGFBPs can also act to guide IGF-1 to specific tissues, or even to inhibit or potentiate IGF-1 actions by acting as an independent substrate for the IGF-1R and/or other specific membrane, intracellular or nuclear receptors [7]

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Interestingly, in humans with B12 deficiency then, that's also been associated with dementia, which might explain why Elizabeth cat was constantly crying and vocalizing

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